Syrian Rue (Peganum harmala) is one of Mother Nature's legal hallucinogenic plants containing seeds rich in harmine, harmaline, and harmalol. It is native mainly to India, the Middle East, and the plains of Spain. In: some Mediterranean marketplaces Syrian Rue is sold commercially as a spice.

Only small doses of Syrian rue should be used when experimenting, since it is an unusually powerful drug whose effects vary widely from person to person.

Small doses of Syrian rue (0.025-0.050g) act as a mild stimulant and produce feelings of drowsiness and dreaminess for about an hour or two. Larger doses (0.3-0.75g) may cause hallucinations. The drug acts upon the central nervous system and' users often feel highly stimulated, experiencing wild visions. In the Middle East, Syrian rue is sometimes mixed with other psychoactive plants for extra kick and potency.